ORIGINAL PAPERS (2021-2024)
Kurotani, R.; Sato, Y.; Okawara, A.; Fukuda, N.; Hada, K.; Sakakura, S.; Takakura, K.; Abe, H.; Konno, H.; Kimura, S. Secretoglobin 3A2 peptide has therapeutic potential for allergic airway inflammation. Life Sci. 2024, in press.
Kainuma, R.; Yano, S.; Konno, H. determination of the amino linkage of D-Dab residue of occidiofungins A-D cyclic lipo-octapeptides and antifungal activity of their analogues. Org. Biomol. Chem. 2024, 22, 6575-6581. DOI: 10.1039/D4OB00900B.
Nakano, A.; Hayashi, A.; Nagaoka, K.; Moriwaki, H.; Izawa, K.; Yano, S.; Konno, H. Dynamic thermodynamic resolution of unprotected amino acids using Ni(II) chiral Schiff bases. Eur. J. Org. Chem. 2024, e202400417. DOI10.1002/ejoc.202400417 .
Takahashi, M.; Yokomichi, M.; Takei, Y.; Horaguchi, Y.; Makabe, K.; Konno, H.; Yano, S.; Kokeguchi, S. Domain structure and function of a-1,3-glucanase Agl-EK14 from the gram-negative bacterium Flavobacterium sp. EK-14. J. Biosci. Bioeng. 2024, in press.
Xu, F.; Takiguchi, Y.; Makabe, K.; Konno, H.* Synthesis and evaluation of catechol amine derivatives as amyloid-beta aggregation inhibitors. Bioorg. Med. Chem. Lett. 2024, 107, 129788. DOI10.1016/j.bmcl.2024.129788
Miura, Y.; Namioka, S.; Iwai, A.; Yoshida, N.; Konno, H.; Sohma, Y.; Kanai, M.; Makabe, K. Redesign of a thioflabin-T-binding protein with a flat b-sheet to evaluate a thioflabin-T-derived photocatalyst with enhanced affinity. Int. J. Biol. Macromol. 2024, 269, 131992. DOI10.1016/j.ijbiomac.2024.131992
Che, S.; Konno, H.; Makabe, K. SpyTag peptide with alkoxyl aspartic acids for pH-dependent activation of the SpyCatcher/Tag system. Bioconjugate Chem. 2024, 35, 616-622. DOI10.1021/acs.bioconjchem.4c00052
Li, Y.; Takamatsu, K.; Aota, T.; Konno, H. Synthesis and structural revision of antatollamides A and B, cyclic hexapeptide dimers. Org. Lett. 2024, 26, 3375-2279. DOI10.1021/acs.orglett.4c00808
Soltan, O. M.; Abdel-Aziz, S.; Shaykoon, M.; Osawa, K.; Narumi, A.; Abdel-Aziz, M.; Konno, H. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, molecular docking, and Bioactivity Evaluation. Bioorg. Med. Chem. Lett. 2024, 102, 129673. DOI10.1016/j.bmcl.2024.129673.
Horaguchi, Y.; Yokomichi, M.; Takahashi, M.; Xu, F.; Konno, H.; Makabe, K.; Yano, S. Addition of α-1,3-glucan-binding domains to α-1,3-glucanase Agn1p from Schizosaccharomyces pombe enhances hydrolytic activity of insoluble α-1,3-glucan. J. Gen. Appl. Microbiol. 2024, in press.
ORIGINAL PAPERS (2023)
Takahashi, M.; Yano, S. Horaguchi, Y.; Otsuka, Y.; Suyotha, W.; Makabe, K.; Konno, H.; Kokeguchi, S. α-1,3-Glucanase from Gram-negative bacteria Flavobacterium sp. EK-14 hydrolyzes fungal cell wall a-1,3-glucan. Sci. Rep. 2023, 13, 21420. DOI10.1038/s41598-023-48627-y.
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Osawa, K.; Abdel-Aziz, M.; Konno, H. Development and assessment of 1,5-diarylpyrazole/oxime hybrids targeting EDFR and JNK-2 as antiproliferative agents: A comprehensive study through synthesis, molecular docking and evaluation. Molecules 2023, 28, 6521. DOI10.3390/molecules28186521.
Xu, F.; Okada, M.; Makabe, K.; Konno, H. Synthesis and evaluation of L-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors. Phytochem. Lett. 2023, 57, 239-247. DOI10.1016/j.phytol.2023.08.014
Okawara, A.; Hada, K.; Kurotani, R.; Teruya, K.; Konno, H. Design of the peptide C-terminus protecting group and application for the peptide fragment coupling reaction. Tetrahedron Lett. 2023, 127, 154665. DOI10.1016/j.tetlet.2023.154665.
Horaguchi, Y.; Takahashi, M.; Takamatsu, K.; Konno, H.; Makabe, K.; Yano, S. Heterologous expression of α-1,3-glucanase Agn1p from Schizosaccharomyces pombe, and efficient production of nigero-oligosaccharides by enzymatic hydrolysis from solubilized α-1,3;1,6-glucan. Biosci. Biotechnol. Biochem. 2023, 87, 1219-1228. DOI10.1093/bbb/zbad094.
Takamatsu, K.; Suzuki, R.; Matsunaga, A.; Katagiri, H.; Konno, H. Structure activity relationship study of NHPI derivatives for ReD-A method and the application for the Fmoc-SPPS. J. Org. Chem. 2023, 88, 1319-1326. DOI10.1021/acs.joc.2cc01342
Horaguchi, Y.; Yano, S.; Takamatsu, K.; Otsuka, Y.; Suyotha, W.; Wakayaama, M.; Konno, H. Nigero-oligosaccharide production by enzymatic hydrolysis from alkaline pretreated a-1,3-glucan. J. Biosci. Bioeng. 2023, 135, 182-189. DOI10.1016/j.biosc.2023.01.003
ORIGINAL PAPERS (2022)
Yano, S.; Terada, S.; Fukushi, M.; Otsuka, Y.; Mizunuma, S.; Asakura, S.; Kawai, T.; Konno, H.; Endo, M.; Nonomura, Y. Antimicrobial activity of polysorbate 80–iodine complex: Polysorbate 80 firmly retains iodine. J. Oleo. Sci. 2022, 71, 1639-1645. DOI10.5650/jos.ess22115
Kadowaki, T.; Kainuma, R.; Kato, S.; Konno, H. Synthesis and configuration confirmation of ATHOD fatty amino acid residue in burkholdines. J. Nat. Prod. 2022, 85, 2052-2061. DOI10.1021/acs.jnatprod.2c00469 = Selected cover picture
Otsuka, Y.; Sato, K.; Yano, S.; Kanno, H.; Tsuhako, H.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. GH16 type β-1,3-glucanase from Lysobacter sp. MK9-1 enhances antifungal activity of GH 19 type chitinase, and its glucan-biding domain binds to fungal cell-wall. J. Appl. Glycosci. 2022, 69, 49-56. DOI10.5458/jag/jag.JAG-2022_0002
Konno, H.; Sasaki, M; Sano, H.; Osawa, K.; Nosaka, K.; Yano, S. Hydrophobicity and antifungal potentiation efficiency of cyclic peptide burkholdine analogues. Molecules 2022, 27, 1191. DOI10.3390/molecules27041191
Otsuka, Y.; Sasaki, K.; Suyotha, W.; Hurusawa, H.; Miyazawa, K.; Konno, H.; Yano, S. Construction of fusion protein consisting of α-1,3-glucan binding domains and tetrameric red fluorescent protein, which is involved in aggregation of α-1,3-glucan and inhibition of fungal biofilm formation. J. Biosci. Bioeng. 2022,133, 524-532. DOI10.1016/j.biosc.2022.02.008
Tan, A.; Takamatsu, K.; Xu, F.; Osanai, S.; Konno, H. Application of reversible detection method for N-terminus amino groups: solid phase synthesis of stylissatin B. Heterocycles 2022, 105, 397-405. DOI10.3987/COM-21-S(R)6
Ito, Y.; Araki, T.; Shiga, S.; Konno, H.; Makabe, K. Surface engineering of TOP7 to facilitate structure determination. Int. J. Mol. Sci. 2022 23, 701. DOI10.3390/ijms23020701
Teruya, K.; Iwabuchi, S.; Watanabe, Y.; Tsuchida, R.; Watanabe-Matsui, M.; Konno, H.; Doh-ura, K. Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains. BBA General Subjects 2022, 1866, 130094. DOI10.1016/j.bbagen.22022.130094
ORIGINAL PAPERS (2021)
Sasaki, M.; Kadowaki, T.; Kato, S.; Chida, S.; Yano, S.; Nosaka, K.; Konno, H. Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues. Tetrahedron Lett. 2021, 87, 153542. DOI10.1016/j.tetlet.2021.153542
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Tajiri, M.; Abdel-Aziz, M.; Konno, H. Design, synthesis, molecular docking and biological evaluation of novel 1,5-diarylpyrazole-N,O-dimethyl hydroxamate derivatives as antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 214-225.
Tan, A.; Xu, F.; Yokoyama, C.; Yano S.; Konno, H. Design, synthesis, and evaluation of the self-assembled antimicrobial peptides derived from the ovalbumin-derived peptide TK913 J. Pept. Sci. 2021, e3375. DOI10.1002/psc.3375
Takamatsu, K.; Kasai, M.; Nishizawa, H.; Suzuki, R.; Konno, H. Aerobic oxidation of aldehydes with N-hydroxyphthalimide derivatives. Tetrahedron Lett. 2021, 81, 153320. DOI10.1016/j.tetlet.2021.153320
Homma, T.; Kobayashi, S.; Marcus, C.; Konno, H.; Yokoyama, C.; Fujii, J. Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide 2021, 115, 34-43. DOI10.1016/j.niox.2021.07.003.
Nagaoka, K.; Nakano, A.; Han, J.; Sakamoto, T.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Comparative study of different chiral ligands for dynamic kinetic resolution of amino acid. Chirality 2021, 33, 685-702. DOI10.1002/chir.23350
Kobayashi, S.; Homma, T.; Okumura, N.; Han, J.; Nagaoka, K.; Sato, H.; Konno, H.; Yamada, S.; Takao, T.; Fujii, J. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Free Radical Bio. Med. 2021, 174, 12- 27.
DOI10.1016/j.freeradbiomed.2021.07.036
Zou, Y.; Yin, Z.; Mei, H.; Konno, H.; Moriwaki, H.; Soloshonok, V. A.; Han, J. Aldol addition-cyclization reaction cascade on platform of chiral Ni(II) complex of glycine Schiff base. Urk. Bioorg. Acta 2021, 16, N1, 3-9. DOI10.15407/bioorganica2021.01.003.
Solman, O. M.; Shoman, M. E.; Abdel-Aziz, S. A.; Nagaoka, K.; Narumi, A.; Konno, H.; Abdel-Aziz M. Design, synthesis, molecular modeling and biological evaluation of novel 1,5-diarylpyrazole carboxamide derivatives s antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 152-159.
Li, Z.; Wang, N.; Mei, H.; Konno, H.; Soloshonok, V. A.; Han, J. Asymmetric Synthesis of a-difluorinated b-amino sulfones via detrifluoroacetylative Mannich reactions. Eur. J. Org. Chem. 2021, 3035-3038. DOI10.1002/ejoc.202100350
Zou, Y.; Takeda, R.; Han, J.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Asymmetric synthesis of N-Fmoc-(S)-7-aza-triptophane via alkylation of chiral nucleophilic glycine equivalent. Eur. J. Org. Chem. 2021, 2962-2965. DOI10.1002/ejoc.202100485
Mihara, H.; Watanabe, Y.; Konno, H. Preparation of pyridine derivatives from the corresponding 5-acetal-1-carbonyl compounds by acid promoted cyclization. Heterocycles 2021, 102, 1314-1329. DOI10.3987/COM-21-14457
Narumi, A.; Rachi, R.; Yamazaki, H.; Kawaguchi, S.; Kikuchi, M.; Konno, H.; Osaki, T.; Okamoto, Y.; Shen, X.; Kakuchi, T.; Kataoka, H.; Nomoto, A.; Yano, S. Maltotriose-chlorin e6 conjugate linked via tetraethyleneglycol as advanced photosensitizer for photodynamic therapy. Synthesis and antitumor tests against canine and mouse mammary carcinoma cells. ACS Omega 2021, 6, 7023-7033. DOI10.1021.qcsomega.0c06316
Tokairin, Y.; Konno, H.; Noireau, A.; Wast, C.; Lesellier, E.; Moriwaki, H.; Soloshonok, V. A.; Nicolas, C.; Gillaizeau, I. Synthesis of the two enantiomers of b-phosphorus-containing amino acids via hydrophosphinylation and hydrophosphonylation of chiral Ni(II)-complexs. Org. Chem. Front. 2021, 8, 2190. DOI10.1039/d1qo00159k
Tajiri, M.; Yamada, R.; Hotsumi, M.; Makabe, K.; Konno, H. The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. Eur. J Med. Chem. 2021, 215, 113289. DOI10.1016/j.ejmch.2021.113289
Alfayomy, A. M.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shaykoon, M. Sh. A.; Narumi, A. Konno, H.; Abou-Seri, S. M.; Ragab, F. A. F. Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies. Bioorg. Chem. 2021, 108, 104555. DOI:10.1016/j.bioorg.2020.104555
Shigeno, Y.; Han, J.; Soloshonok, V. A.; Moriwaki, H.; Fujiwara, W.; Konno, H. Asymmetric synthesis of (S)-3-methyleneglutamic acid and its N-Fmoc derivative via Michael addition of chiral glycine Schiff base Ni(II) complex with enol tosylates. Chirality 2021, 33, 115-123. DOI10.10072/chir.23291
Yano, S.; Kanno, H.; Tsunako, H.; Ogasawara, S.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. Cloning, expression, and characterization of a GH 19 type chitonase with antifungal activity from Lysobacter sp. MK9-1. J. Biosci. Bioeng. 2021, 131, 348-355.
Suyotha, W.; Cheirslip, B.; Matsuba, S.; Konno, H.; Yano, S. Production of chitosanase by Lentzea sp. OUR-I1 using acid-pretreated shrimp shell in an air-lift bioreactor and the feasibility of utilizing the residual biomass. Waste and Biomass Valorization 2021, 12, 2445-2458. DOI10.1071/s12649-020-01191-2
REVIEW ARTICLES
Javahershenas, R.; Han, J.; Liu, H.; Wang, J.; Wzorek, A.; Sorochinsky, A. E.; Ono, T.; Moriwaki, H.; Sato, T.; Izawa, K.; Konno, H.; Soloshonok, V. A. Hamari’s contribution to the asymmetric synthesis of tailor-made amino acids. Ukrainica Bioorganica Acta 2024, in press.
Abdellatif, A. A.; Mostafa, M. A. H.; Konno, H.; Younis, M. A. Exploring the green synthesis of silver nanoparticles using natural effects and their potential for cancer treatment. 3Biotech, 2024, in press.
Soltan, O. M.; Abdelrahman, K. S.; Bass, A. K. A.; Takizawa, K.; Narumi, A.; Konno, H. Design of Multi-Target Drugs of HDACs and Other Anti-Alzheimer Related Targets: Current Strategies and Future Prospects in Alzheimer’s Diseases Therapy. Bioorg. Chem. 2024, 151, 107651. DOI10.1016/j.bioorg.2024.107651
Konno, H.; Teruya, K. Design, synthesis and evaluation of catechol-based amyloid beta aggregation inhibitors. Heterocycles 2023, 106, 797-818. DOI: 10.3987/REV-22-999
今野博行, N-ヒドロキシフタルイミドの特性を活かした新しい活用法. Peptide Newsletter Japan, 2021年10月, No. 122, pp2-5.
Liu, A.; Han, J.; Nakano, A.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. New pharmaceuticals approved by FDA in 2020: small-molecule drugs derived from amino acids and related compounds. Chirality 2021, 34, 86-103. DOI10.1002/chir.23376
Han, J.; Lyutenko, N. V.; Sorochinsky, A. E.; Okawara, A.; Konno, H.; White, S.; Soloshonok, V. A. Tailar-made amino acids in pharmaceutical industry: synthetic approaches to aza-tryptophan detivatives. Chem. Eur. J. 2021, 27, 17510-17528. DOI10.1002/chem.202102485 = Selected Frontispiece Picture
Soltan, O.; Shoman, M.; Abdel-Aziz, S.; Narumi, A.; Konno, H.; Abdel-Aziz, M. Molecular hybrids: A five years survey on structure of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. Eur. J. Med. Chem. 2021, 225, 113768. DOI10.1016/j.ejmech.2021.113768
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Peptidemimetics and peptide-based blockbuster drugs. Curr. Org. Chem. 2021, 25, 1627-1658. DOI10.2174/1385272825666210610155047
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Tailor-made amino acids in the design of small-molecule blockbuster drugs. Eur. J. Med. Chem. 2021, 220, 113448. DOI10.1016/j.ejmech.2021.113448
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S.; Marzouk, A.; Narumi, A.; Konno, H.; Abdel-Aziz, M. JNK signaling as target for anticancer therapy. Pharmacological Reports 2021,73, 405-434. DOI10.1007/s43440-021-00238-y
今野博行、赤路健一、コロナウイルスSARS 3CL プロテアーゼの作製とその阻害剤創製. 有機合成化学協会誌, 2021,79, 2-10.