ORIGINAL PAPERS (2021-2024)

ORIGINAL PAPERS (2024)
 
Kurotani, R.; Sato, Y.; Okawara, A.; Fukuda, N.; Hada, K.; Sakakura, S.; Takakura, K.; Abe, H.; Konno, H.; Kimura, S. Secretoglobin 3A2 peptide has therapeutic potential for allergic airway inflammation. Life Sci. 2024, in press.
 
Kainuma, R.; Yano, S.; Konno, H. determination of the amino linkage of D-Dab residue of occidiofungins A-D cyclic lipo-octapeptides and antifungal activity of their analogues. Org. Biomol. Chem. 2024, 22, 6575-6581. DOI: 10.1039/D4OB00900B.
 
Nakano, A.; Hayashi, A.; Nagaoka, K.; Moriwaki, H.; Izawa, K.; Yano, S.; Konno, H. Dynamic thermodynamic resolution of unprotected amino acids using Ni(II) chiral Schiff bases. Eur. J. Org. Chem. 2024,  e202400417. DOI10.1002/ejoc.202400417 .
 
Takahashi, M.; Yokomichi, M.; Takei, Y.; Horaguchi, Y.; Makabe, K.; Konno, H.; Yano, S.; Kokeguchi, S. Domain structure and function of a-1,3-glucanase Agl-EK14 from the gram-negative bacterium Flavobacterium sp. EK-14. J. Biosci. Bioeng. 2024, in press.
 
Xu, F.; Takiguchi, Y.; Makabe, K.; Konno, H.* Synthesis and evaluation of catechol amine derivatives as amyloid-beta aggregation inhibitors. Bioorg. Med. Chem. Lett. 2024, 107, 129788. DOI10.1016/j.bmcl.2024.129788
 
Miura, Y.; Namioka, S.; Iwai, A.; Yoshida, N.; Konno, H.; Sohma, Y.; Kanai, M.; Makabe, K. Redesign of a thioflabin-T-binding protein with a flat b-sheet to evaluate a thioflabin-T-derived photocatalyst with enhanced affinity. Int. J. Biol. Macromol. 2024, 269, 131992. DOI10.1016/j.ijbiomac.2024.131992
 
Che, S.; Konno, H.; Makabe, K. SpyTag peptide with alkoxyl aspartic acids for pH-dependent activation of the SpyCatcher/Tag system. Bioconjugate Chem. 2024, 35, 616-622.  DOI10.1021/acs.bioconjchem.4c00052
 
Li, Y.; Takamatsu, K.; Aota, T.; Konno, H. Synthesis and structural revision of antatollamides A and B, cyclic hexapeptide dimers. Org. Lett. 2024, 26, 3375-2279. DOI10.1021/acs.orglett.4c00808
 

 
Soltan, O. M.; Abdel-Aziz, S.; Shaykoon, M.; Osawa, K.; Narumi, A.; Abdel-Aziz, M.; Konno, H. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, molecular docking, and Bioactivity Evaluation. Bioorg. Med. Chem. Lett. 2024, 102, 129673. DOI10.1016/j.bmcl.2024.129673.
 

 
Horaguchi, Y.; Yokomichi, M.; Takahashi, M.; Xu, F.; Konno, H.; Makabe, K.; Yano, S. Addition of α-1,3-glucan-binding domains to α-1,3-glucanase Agn1p from Schizosaccharomyces pombe enhances hydrolytic activity of insoluble α-1,3-glucan. J. Gen. Appl. Microbiol. 2024, in press.
 
ORIGINAL PAPERS (2023)
 
Takahashi, M.; Yano, S. Horaguchi, Y.; Otsuka, Y.; Suyotha, W.; Makabe, K.; Konno, H.; Kokeguchi, S. α-1,3-Glucanase from Gram-negative bacteria Flavobacterium sp. EK-14 hydrolyzes fungal cell wall a-1,3-glucan. Sci. Rep. 2023, 13, 21420. DOI10.1038/s41598-023-48627-y.
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Osawa, K.; Abdel-Aziz, M.; Konno, H. Development and assessment of 1,5-diarylpyrazole/oxime hybrids targeting EDFR and JNK-2 as antiproliferative agents: A comprehensive study through synthesis, molecular docking and evaluation. Molecules 2023, 28, 6521. DOI10.3390/molecules28186521.
 
Xu, F.; Okada, M.; Makabe, K.; Konno, H. Synthesis and evaluation of L-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors. Phytochem. Lett. 2023, 57, 239-247. DOI10.1016/j.phytol.2023.08.014
 
Okawara, A.; Hada, K.; Kurotani, R.; Teruya, K.; Konno, H. Design of the peptide C-terminus protecting group and application for the peptide fragment coupling reaction. Tetrahedron Lett. 2023, 127, 154665. DOI10.1016/j.tetlet.2023.154665.
 
Horaguchi, Y.; Takahashi, M.; Takamatsu, K.; Konno, H.; Makabe, K.; Yano, S. Heterologous expression of α-1,3-glucanase Agn1p from Schizosaccharomyces pombe, and efficient production of nigero-oligosaccharides by enzymatic hydrolysis from solubilized α-1,3;1,6-glucan. Biosci. Biotechnol. Biochem. 2023, 87, 1219-1228. DOI10.1093/bbb/zbad094.
 
Takamatsu, K.; Suzuki, R.; Matsunaga, A.; Katagiri, H.; Konno, H. Structure activity relationship study of NHPI derivatives for ReD-A method and the application for the Fmoc-SPPS. J. Org. Chem. 2023, 88, 1319-1326. DOI10.1021/acs.joc.2cc01342
 
Horaguchi, Y.; Yano, S.; Takamatsu, K.; Otsuka, Y.; Suyotha, W.; Wakayaama, M.; Konno, H. Nigero-oligosaccharide production by enzymatic hydrolysis from alkaline pretreated a-1,3-glucan. J. Biosci. Bioeng. 2023, 135, 182-189. DOI10.1016/j.biosc.2023.01.003
 
 
ORIGINAL PAPERS (2022)
 
Yano, S.; Terada, S.; Fukushi, M.; Otsuka, Y.; Mizunuma, S.; Asakura, S.; Kawai, T.; Konno, H.; Endo, M.; Nonomura, Y. Antimicrobial activity of polysorbate 80–iodine complex: Polysorbate 80 firmly retains iodine. J. Oleo. Sci. 2022, 71, 1639-1645. DOI10.5650/jos.ess22115
 
Kadowaki, T.; Kainuma, R.; Kato, S.; Konno, H. Synthesis and configuration confirmation of ATHOD fatty amino acid residue in burkholdines. J. Nat. Prod. 2022, 85, 2052-2061. DOI10.1021/acs.jnatprod.2c00469 = Selected cover picture
 
Otsuka, Y.; Sato, K.; Yano, S.; Kanno, H.; Tsuhako, H.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. GH16 type β-1,3-glucanase from Lysobacter sp. MK9-1 enhances antifungal activity of GH 19 type chitinase, and its glucan-biding domain binds to fungal cell-wall. J. Appl. Glycosci. 2022, 69, 49-56. DOI10.5458/jag/jag.JAG-2022_0002
 
Konno, H.; Sasaki, M; Sano, H.; Osawa, K.; Nosaka, K.; Yano, S. Hydrophobicity and antifungal potentiation efficiency of cyclic peptide burkholdine analogues. Molecules 2022, 27, 1191. DOI10.3390/molecules27041191
 
Otsuka, Y.; Sasaki, K.; Suyotha, W.; Hurusawa, H.; Miyazawa, K.; Konno, H.; Yano, S. Construction of fusion protein consisting of α-1,3-glucan binding domains and tetrameric red fluorescent protein, which is involved in aggregation of α-1,3-glucan and inhibition of fungal biofilm formation. J. Biosci. Bioeng. 2022,133, 524-532. DOI10.1016/j.biosc.2022.02.008
 
Tan, A.; Takamatsu, K.; Xu, F.; Osanai, S.; Konno, H. Application of reversible detection method for N-terminus amino groups: solid phase synthesis of stylissatin B. Heterocycles 2022105, 397-405. DOI10.3987/COM-21-S(R)6
 
Ito, Y.; Araki, T.; Shiga, S.; Konno, H.; Makabe, K. Surface engineering of TOP7 to facilitate structure determination. Int. J. Mol. Sci. 2022 23, 701. DOI10.3390/ijms23020701
 
Teruya, K.; Iwabuchi, S.; Watanabe, Y.; Tsuchida, R.; Watanabe-Matsui, M.; Konno, H.; Doh-ura, K. Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains. BBA General Subjects 2022, 1866, 130094. DOI10.1016/j.bbagen.22022.130094
 
 
ORIGINAL PAPERS (2021)
 
 
Sasaki, M.; Kadowaki, T.; Kato, S.; Chida, S.; Yano, S.; Nosaka, K.; Konno, H. Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues. Tetrahedron Lett. 2021, 87, 153542.  DOI10.1016/j.tetlet.2021.153542
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Tajiri, M.; Abdel-Aziz, M.; Konno, H. Design, synthesis, molecular docking and biological evaluation of novel 1,5-diarylpyrazole-N,O-dimethyl hydroxamate derivatives as antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 214-225.
 
Tan, A.; Xu, F.; Yokoyama, C.; Yano S.; Konno, H. Design, synthesis, and evaluation of the self-assembled antimicrobial peptides derived from the ovalbumin-derived peptide TK913 J. Pept. Sci. 2021, e3375. DOI10.1002/psc.3375
 
Takamatsu, K.; Kasai, M.; Nishizawa, H.; Suzuki, R.; Konno, H. Aerobic oxidation of aldehydes with N-hydroxyphthalimide derivatives. Tetrahedron Lett. 2021, 81, 153320. DOI10.1016/j.tetlet.2021.153320
 
Homma, T.; Kobayashi, S.; Marcus, C.; Konno, H.; Yokoyama, C.; Fujii, J. Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide 2021, 115, 34-43.  DOI10.1016/j.niox.2021.07.003.
 
Nagaoka, K.; Nakano, A.; Han, J.; Sakamoto, T.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Comparative study of different chiral ligands for dynamic kinetic resolution of amino acid. Chirality 2021, 33,  685-702. DOI10.1002/chir.23350
 
Kobayashi, S.; Homma, T.; Okumura, N.; Han, J.; Nagaoka, K.; Sato, H.; Konno, H.; Yamada, S.; Takao, T.; Fujii, J. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Free Radical Bio. Med. 2021, 174, 12- 27. 
DOI10.1016/j.freeradbiomed.2021.07.036
 
Zou, Y.; Yin, Z.; Mei, H.; Konno, H.; Moriwaki, H.; Soloshonok, V. A.; Han, J. Aldol addition-cyclization reaction cascade on platform of chiral Ni(II) complex of glycine Schiff base. Urk. Bioorg. Acta 2021, 16, N1, 3-9. DOI10.15407/bioorganica2021.01.003.
 
Solman, O. M.; Shoman, M. E.; Abdel-Aziz, S. A.; Nagaoka, K.; Narumi, A.; Konno, H.; Abdel-Aziz M. Design, synthesis, molecular modeling and biological evaluation of novel 1,5-diarylpyrazole carboxamide derivatives s antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 152-159.
 
Li, Z.; Wang, N.; Mei, H.; Konno, H.; Soloshonok, V. A.; Han, J. Asymmetric Synthesis of a-difluorinated b-amino sulfones via detrifluoroacetylative Mannich reactions. Eur. J. Org. Chem. 2021, 3035-3038. DOI10.1002/ejoc.202100350
 
Zou, Y.; Takeda, R.; Han, J.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Asymmetric synthesis of N-Fmoc-(S)-7-aza-triptophane via alkylation of chiral nucleophilic glycine equivalent. Eur. J. Org. Chem. 2021, 2962-2965.  DOI10.1002/ejoc.202100485
 
Mihara, H.; Watanabe, Y.; Konno, H. Preparation of pyridine derivatives from the corresponding 5-acetal-1-carbonyl compounds by acid promoted cyclization. Heterocycles 2021, 102, 1314-1329. DOI10.3987/COM-21-14457
 
Narumi, A.; Rachi, R.; Yamazaki, H.; Kawaguchi, S.; Kikuchi, M.; Konno, H.; Osaki, T.; Okamoto, Y.; Shen, X.; Kakuchi, T.; Kataoka, H.; Nomoto, A.; Yano, S. Maltotriose-chlorin e6 conjugate linked via tetraethyleneglycol as advanced photosensitizer for photodynamic therapy. Synthesis and antitumor tests against canine and mouse mammary carcinoma cells. ACS Omega 2021, 6, 7023-7033. DOI10.1021.qcsomega.0c06316
 
Tokairin, Y.; Konno, H.; Noireau, A.; Wast, C.; Lesellier, E.; Moriwaki, H.; Soloshonok, V. A.; Nicolas, C.; Gillaizeau, I. Synthesis of the two enantiomers of b-phosphorus-containing amino acids via hydrophosphinylation and hydrophosphonylation of chiral Ni(II)-complexs. Org. Chem. Front. 2021, 8, 2190. DOI10.1039/d1qo00159k
 
Tajiri, M.; Yamada, R.; Hotsumi, M.; Makabe, K.; Konno, H. The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. Eur. J Med. Chem. 2021215, 113289. DOI10.1016/j.ejmch.2021.113289
 
Alfayomy, A. M.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shaykoon, M. Sh. A.; Narumi, A. Konno, H.; Abou-Seri, S. M.; Ragab, F. A. F. Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies. Bioorg. Chem. 2021, 108, 104555. DOI:10.1016/j.bioorg.2020.104555
 
Shigeno, Y.; Han, J.; Soloshonok, V. A.; Moriwaki, H.; Fujiwara, W.; Konno, H. Asymmetric synthesis of (S)-3-methyleneglutamic acid and its N-Fmoc derivative via Michael addition of chiral glycine Schiff base Ni(II) complex with enol tosylates. Chirality 2021, 33, 115-123. DOI10.10072/chir.23291
 
Yano, S.; Kanno, H.; Tsunako, H.; Ogasawara, S.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. Cloning, expression, and characterization of a GH 19 type chitonase with antifungal activity from Lysobacter sp. MK9-1. J. Biosci. Bioeng. 2021, 131, 348-355.
 
Suyotha, W.; Cheirslip, B.; Matsuba, S.; Konno, H.; Yano, S. Production of chitosanase by Lentzea sp. OUR-I1 using acid-pretreated shrimp shell in an air-lift bioreactor and the feasibility of utilizing the residual biomass. Waste and Biomass Valorization 2021, 12, 2445-2458. DOI10.1071/s12649-020-01191-2
 
 
 
 

REVIEW ARTICLES

 
Javahershenas, R.; Han, J.; Liu, H.; Wang, J.; Wzorek, A.; Sorochinsky, A. E.; Ono, T.; Moriwaki, H.; Sato, T.; Izawa, K.; Konno, H.; Soloshonok, V. A. Hamari’s contribution to the asymmetric synthesis of tailor-made amino acids. Ukrainica Bioorganica Acta 2024, in press.
 
Abdellatif, A. A.; Mostafa, M. A. H.; Konno, H.; Younis, M. A. Exploring the green synthesis of silver nanoparticles using natural effects and their potential for cancer treatment. 3Biotech, 2024, in press.
 
Soltan, O. M.; Abdelrahman, K. S.; Bass, A. K. A.; Takizawa, K.; Narumi, A.; Konno, H. Design of Multi-Target Drugs of HDACs and Other Anti-Alzheimer Related Targets: Current Strategies and Future Prospects in Alzheimer’s Diseases Therapy. Bioorg. Chem. 2024, 151, 107651. DOI10.1016/j.bioorg.2024.107651
 
Konno, H.; Teruya, K. Design, synthesis and evaluation of catechol-based amyloid beta aggregation inhibitors. Heterocycles 2023, 106, 797-818. DOI: 10.3987/REV-22-999
 
今野博行, N-ヒドロキシフタルイミドの特性を活かした新しい活用法. Peptide Newsletter Japan, 2021年10月, No. 122, pp2-5.
 
Liu, A.; Han, J.; Nakano, A.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. New pharmaceuticals approved by FDA in 2020: small-molecule drugs derived from amino acids and related compounds. Chirality 2021, 34, 86-103. DOI10.1002/chir.23376
 
Han, J.; Lyutenko, N. V.; Sorochinsky, A. E.; Okawara, A.; Konno, H.; White, S.; Soloshonok, V. A. Tailar-made amino acids in pharmaceutical industry: synthetic approaches to aza-tryptophan detivatives.  Chem. Eur. J. 2021, 27, 17510-17528. DOI10.1002/chem.202102485 = Selected Frontispiece Picture
 
Soltan, O.; Shoman, M.; Abdel-Aziz, S.; Narumi, A.; Konno, H.; Abdel-Aziz, M. Molecular hybrids: A five years survey on structure of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. Eur. J. Med. Chem. 2021, 225, 113768. DOI10.1016/j.ejmech.2021.113768
 
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Peptidemimetics and peptide-based blockbuster drugs. Curr. Org. Chem. 2021, 25, 1627-1658. DOI10.2174/1385272825666210610155047
 
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Tailor-made amino acids in the design of small-molecule blockbuster drugs. Eur. J. Med. Chem. 2021220, 113448. DOI10.1016/j.ejmech.2021.113448
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S.; Marzouk, A.; Narumi, A.; Konno, H.; Abdel-Aziz, M. JNK signaling as target for anticancer therapy. Pharmacological Reports 2021,73, 405-434. DOI10.1007/s43440-021-00238-y
 
今野博行、赤路健一、コロナウイルスSARS 3CL プロテアーゼの作製とその阻害剤創製. 有機合成化学協会誌, 2021,79, 2-10.
 


Presentations

 
2024
 
○Rin Kainuma, Shigekazu Yano, Hiroyuki Konno. Determination of D-Dab desidue linkage site of occidifungins A-D and evaluation of their antifungals. 第61回ペプチド討論会(2024年10月29-31日, 名古屋、名古屋大学)
 
○Hinata Sano, Keito Oikawa, Riri Oba, Ryusei Endo, Sota Kumagai, Shigekazu Yano, Koki Makabe, Kenta Teruya, and Hiroyuki Konno. Synthesis and evaluation of phthalimide type SARS-CoV-2 3CL protease inhibitors. 第61回ペプチド討論会(2024年10月29-31日, 名古屋、名古屋大学)
 
○Kenta Teruya, Ayumi Ogura, Sara Iwabuchi, Michiko Okuda, Hiroyuki Konno, Hachiro Sugimoto, Katsumi Doh-ura, Therapeutic effect of curcumin derivative GT863 on PRP-amuloid and prion-infected cells and mice. 第61回ペプチド討論会(2024年10月29-31日, 名古屋、名古屋大学)
 
○大内里菜, 徐復生, 今野博行, b-カルボリンアルカロイド Fascaplysinの誘導体とその評価. 化学フェスタ(2024年10月22-24日, 東京, 船堀タワーホール)
 
○中島健太, Li Yitong, 高松啓吾, 今野博行, 固相上でのアミド結合形成反応を追跡する可逆的アミノ基検出技術. 化学フェスタ(2024年10月22-24日, 東京, 船堀タワーホール)
 
○Yitong Li, 高松啓吾, 青田太一, 今野博行, 環状ヘキサペプチド二量体構造を有するAntatollamides A ならびに B の構造改訂と細胞毒性試験, 日本農芸化学会東北支部会2024年度大会(2024年9月28日, 福島, 福島大学)
 
○Ling Hanyu, Hinata Sano, Kazuma Doi, Hiroyuki Konno, Microwave-assisted oxidation by N-hydroxynaphthalimide catalyst. 化学系学協会東北大会(秋田)(2024年9月13-14日, 秋田市, 秋田大学)
 
○滝口裕也, 徐復生, 真壁幸樹, 今野博行, アミロイドb凝集を阻害するポリカテコールアミンの設計, 合成, 評価 化学系学協会東北大会(秋田)(2024年9月13-14日, 秋田市, 秋田大学)
 
Hiroyuki Konno, Reversible detection method of amino groups during Fmoc-SPPS and its application for the peptidyl natural product synthesis. Invited Lecture of Yaounde I Universiy (9/10/2024, Department of Chemistry, Yaounde I Universiy, Yaounde, Cameroon) Invited from Prof. Turibio Kuiate Tabopda.
 
○横道萌, 菅野春樹, 真壁幸樹, 今野博行, 矢野成和, Lysobacter sp. MK9-1由来耐熱性キチナーゼChi19MKの構造解析,日本農芸化学会2023年度大会(2024年3月24-27日, 東京, 東京農業大学)
 
○佐野陽菜, 遠藤龍生, 照屋健太, 服部恭尚, 矢野成和, 今野博行, Synthesis and evaluation of phthalimide type inhibitors against SARS-CoV 3CL protease, 日本農芸化学会2023年度大会(2024年3月24-27日, 東京, 東京農業大学)
 
○Yitong Li, Keigo Takahmatsu, Hiroyuki Konno, Synthesis ans structural elucidaton of antatollamide A and its derivatives, 日本農芸化学会2023年度大会(2024年3月24-27日, 東京, 東京農業大学)
 
2023
 
Kazuki Takizawa and Hiroyuki Konno, Biological evaluation of COX-2 inhibition and synthetic study of fluorescent probe, YU-COEseminar 2023, Drug Discovery & Chemical Biology (December 18, 2023, Tsuruoka, Yamagata, Japan)
 
Seren Osanai and Hiroyuki Konno, Synthesis of Stylissamide H: Applied reversible detection method for amino group "ReD-A method, YU-COEseminar 2023, Drug Discovery & Chemical Biology (December 18, 2023, Tsuruoka, Yamagata, Japan)
 
○徐復生, 機能性分子の創製に向けた生物有機化学的評価, 日本農芸化学会東北支部会(2023年12月2日, 仙台市, 東北大学)-東北支部若手奨励賞-
 
○海沼凜, 門脇斗真, 今野博行, Occidiofungin Bの化学構造ならびに抗新菌活性に関する研究, 日本農芸化学会東北支部会(2023年12月2日, 仙台市, 東北大学)-東北支部若手の会優秀発表賞-
 
○長谷川諒人, 横尾龍海, 今野博行, Polyoxometalateを用いたペプチドのジスルフィド形成反応, 日本農芸化学会東北支部会(2023年12月2日, 仙台市, 東北大学)
 
○高橋将毅, 矢野成和,真壁幸樹, 今野博行, 苔口進, Flavobacterium sp. EK-14由来a-1,3-グルカナーゼのC-末端領域の役割, 日本農芸化学会東北支部会(2023年12月2日, 仙台市, 東北大学)-優秀発表賞-
 
○Fusheng Xu, Miyu Okada, Koki Makabe, Hiroyuki Konno, DESIGN, SYNTHESIS AND EVALUATION OF DOPA AND CATECHOLAMINE DERIVATIES AS AN AMYLOID-BETA AGGREATION INHIBOTOR. 第60回ペプチド討論会(2023年11月8-10日, 大津、滋賀県立芸術劇場, ピアザ淡海)
 
○Ryusei Endo, Hinata Sano, Moe Yokomichi, Koki Makabe, Shigekazu Yano, Yasunao Hattori, Kenta Teruya, Hiroyuki Konno, PREPARATION OF SARS-COV-2 3CL PROTEASE AND INVESTIGATION OF ITS SUBSTRATE RECOGNITION. 第60回ペプチド討論会(2023年11月8-10日, 大津、滋賀県立芸術劇場, ピアザ淡海)
 
今野博行, ペプチドエンジニアリング:米沢工業会ペプチド製造技術の効率化と多様性創出, 青森支部講演会(2023年10月28日, 青森市, アップルパレス)
 
○岡田実優, 田尻美理, 真壁幸樹, 今野博行, Berberineとその誘導体の合成ならびにAb凝集阻害活性評価, 複素環化学討論会(宮城) (2023年10月13-14日, 仙台市, 東北大学)
 
Fusheng Xu, Miyu Okada, Misato Tajiri, Koki Makabe, Hiroyuki Konno, Synthesis and evaluation of L-dopa derivatives as an amyloid-beta aggregation inhibitor. 16th Asian Conference of Analytical Sciences 2023 nad 19th Asia-Pacific International Syposium on Microscale Separations and Analysis (10/8-13/2024Kuala Lumpur City Centre, Kuala Lumpur, Malaysia)
 
Hioyuki Konno, Reversible detection method of amino groups during Fmoc-solid phase peptide synthesis, Asai-Pacific international symposium on microscale separations and analysis 2023 (APCE2023) (10/8-13/2024, Kuala Lumpur Convention Centre, Kuala Lumpur, Malaysia) Keynote lecture
 
今野博行, アミロイドb凝集阻害効果を持つポリフェノール誘導体の創製, YU-COE(創薬)セミナー (2023年9月14日, 米沢市、山形大学工学部)
 
○中野有那,森脇浩樹, 今野博行, Preparation of D-Amino Acid Derivatives by Dynamic Kinetic Resolution on Ni(II) Chiral Schiff Bases. 化学系学協会東北大会(宮城)(2023年9月9-11日, 仙台市, 東北大学青葉山コモンズ)
 
○羽田健吾, 大河原彩花, 黒谷玲子, 今野博行, Preparation of vinyl handles as the C-terminal protecting groups and its application for peptide synthesis. 化学系学協会東北大会(宮城) (2023年9月9-11日, 仙台市, 東北大学青葉山コモンズ)
 
今野博行, ペプチドエンジニアリング: ペプチド製造技術の効率化と多様性創出, 米沢工業会東京支部講演会(2023年9月9日, 東京, 田町グランパークカンファレンス)
 
今野博行, ペプチドエンジニアリング:ペプチド製造技術の効率化と多様性創出, 米沢工業会北海道支部講演会(2023年7月14日, 札幌市, 北二条クラブ)
 
○佐野陽菜, 及川慧人, 照屋健太, 服部恭尚, 赤路健一, 矢野成和, 今野博行,フタルイミド型SARS-CoV 3CL protease阻害剤の構造活性相関研究, 日本農芸化学会2023年度大会 2E08-06(2023年3月15-18日, 広島, 広島大学)=オンライン開催=トピックス賞
 
○岡田実優, 徐復生, 田尻美理, 真壁幸樹, 今野博行, Heck反応を用いたBerberine誘導体の合成と評価, 日本農芸化学会2023年度大会 2E08-05(2023年3月15-18日, 広島, 広島大学)=オンライン開催=
 
○高橋将毅, 今野博行, 苔口進, 矢野成和, Flavobacterium sp. EK-14由来a-1,3-グルカナーゼAgl-EK14のドメイン構造と機能解析, 日本農芸化学会2023年度大会 1B09-05(2023年3月15-18日, 広島, 広島大学)=オンライン開催=
 
○Fusheng Xu, Miyu Okada, Misato Tajiri, Koki Makabe, Hiroyuki Konno, Synthesis and evaluation of catechol derivatives as an amyloid-beta aggregation inhibitor,日本化学会2023年度大会 (2023年3月22-25日, 野田市, 東京理科大学)
 
○Rin Kainuma, Toma Kadowaki, Hiroyuki konno, Structural Analysis of ATHOD The Fatty Amino Acid and ATHOD-containing Peptides Burkholdines and Occidiofungins日本化学会2023年度大会 (2023年3月22-25日, 野田市, 東京理科大学)
 
○羽田健悟, 大河原彩花, 黒谷玲子, 今野博行, 保護ペプチドのフラグメントカップリング反応に向けたC末端保護基の設計と適用, 日本化学会2023年度大会(2023年3月22-25日, 野田市, 東京理科大学)
 
○海沼凜, 門脇斗真, 今野博行, 抗真菌活性を有するBurkholdineならびにOccidiofunginの化学構造に関する研究, 第34回万有仙台シンポジウム P-9 (2023年4月22日, 仙台市, 東北大学)
 
○蔡誠志, 今野博行, 真壁幸樹, Spycatcher/Tagのイソペプチド結合形成のpH依存的活性化を目指したSpyTagバリアントペプチドの合成, 第23回蛋白質科学会 (2023年7月5-7日, 名古屋, 名古屋国際会議場)