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Publication List

Original Paper


2017

72. Murai, Y.; Mori, S.; Konno H.; Hikichi, Y.; Kai, K. Ralstonins A and B, unusual lipopeptides with chlamydospore-inducing and phytotoxic activities from the plant pathogen Ralstonia solanacearum. Org. Lett. in press.
71. Konno, H.; Onuma, T.; Nitanai, I.; Wakabayashi, M.; Yano, S.; Teruya, K.; Akaji, K. Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor. Bioorg. Med. Chem. Lett. 2017, 27,2746-2751.
70. Yoshino, R.; Tokairin, Y.; Konno, H. Synthesis of fully protected (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy heptanoic acid. Tetrahedron Lett., 2017, 58, 1604-1606.
69. Yoshino, R.; Tokairin, Y.; Kikuchi, M.; Konno, H. Fmoc-OPhth, the reagent of Fmoc protection. Tetrahedron Lett., 2017, 58, 1600-1603.
68. Tokairin, Y.; Konno, H. Preparation of (2R,3R,4R)-3-hydroxy-2,4,6-trimethyl heptanoic acid via enzymatic desymmetrization. Tetrahedron 2017, 73, 39-45.

2016

67. Konno, H.; Wakabayashi, M.; Takanuma, D.; Saito, Y.; Akaji, K. Design and Synthesis of a Series of Serine Derivatives as the Small Molecule Inhibitors of the SARS Coronavirus 3CL Protease. Bioorg. Med. Chem. 2016, 24, 1241-1254.
66. Konno, H.; Sasaki, Y.; Sato, R.; Zhu, X.-M.; Otsuki, Y.; Ikoma, M. Synthesis of β-Hydroxytyrosine, A Component of Burkholdines. Nat. Prod. Commun. 2016, 11, 213-218.
65. Kikuchi, M.; Konno, H. Cytotoxic evaluation of natural and synthetic callipeltins: a revision of cytotoxicity of callipeltin B. Bioscience, Biotechnology, & Biochemistry 2016, 80, 1066-1069.

2015

64. Konno, H.; Sato, T.; Saito Y.; Sakamoto, I.; Akaji, K. Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25, 5127-5132.
63. Konno, H.; Abumi, K.; Sasaki, Y.; Yano, S.; Nosaka, K. Structure activity relationship study of burkholdine analogues toward simple antifungal agents. Bioorg. Med. Chem. Lett. 2015, 25, 3199-3202.
62. Tokairin, Y.; Takeda, S.; Kikuchi, M.; Konno, H. Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment. Tetrahedron Lett. 2015, 56, 2809-2812.
61. Konno, H.; Sema, Y.; Tokairin, Y. Synthetic study of peptide aldehydes via acetal/thioacetal transformation: application for Lys/Ser-containing peptides. Tetrahedron 2015, 71, 3433-3438.
60. Tokairin, Y.; Maita, K.; Takeda, S.; Konno, H. Synthesis of orthogonally protected (2R,3R,4S)-4-amino-2,3-dihydroheptan-1,7-dioic acid. Synthesis 2015, 47, 351-358.

2014

59. Endo, H.; Nikaido, Y.; Nakadate, M.; Ise, S.; Konno, H. Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor. Bioorg. Med. Chem. Lett. 2014, 24, 5621-5626.
58. Kikuchi, M.; Konno, H. Total synthesis of callipeltin B and M, peptidyl marine natural products. Org. Lett. 2014, 16, 4324-4327.
57. Kikuchi, M.; Konno, H. Stereochemical assignment of four diastereomers of dimethylpyroglutamic acid, a component of callipeltin B. Heterocycles 2014, 89(7), 1620-1631.
56. Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K. Effect of prime-site sequence of retro-inverso-modified HTLV-1 protease inhibitor. Bioorg. Med. Chem. 2014, 22, 2482-2488.
55. Hayashi, M.; Kobayashi, K.; Esaki, H.; Konno, H.; Akaji, K.; Tazuya, K.; Yamada, K.; Nosaka, K. Enzymatic and structural characterization of an archaeal thiamin phosphate synthase. BBA-Proteins and Proteomics 2014, 1844, 803-809.
54. Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjoh, A.; Kobayashi, K.; Hattori, Y.; Akaji, K. Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.Bioorg. Med. Chem. Lett. 2014, 24, 685-690.

2013

53. Kurogome, Y.; Kosugi, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H. Total synthesis of (+)-azimine via diastereoselective aminopalladation. Tetrahedron 2013, 69, 8349-8352.
52. Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K. Practical synthesis of peptide C-terminal aldehyde on a solid support. Tetrahedron Lett. 2013, 54, 4848-4850.
51. Konno, H.; Otsuki, Y.; Matsuzaki, K.; Nosaka, K. Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues. Bioorg. Med. Chem. Lett. 2013, 23, 4244-4247.
50. Kikuchi, M.; Konno, H. Improved synthesis of Fmoc-D-allothreonine derivatives from L-threonine. Tetrahedron 2013, 69,7098-7101.

2012

49. Furukawa, H.; Watanabe, K.; Konno, H.; Matsushima, Y.; Matsuba, G.; Nomoto, K. Education project for Innovation, Executed in Faculty of Engineering at Yamagata University in 2010 –Two Education programs about biomass and snow vehicle-. J. Engineering Edu. Res. 2012, 14 (2), 21-29.
48. Nosaka, K.; Esaki, H.; Onozuka, M.; Konno, H.; Hattori, Y.; Akaji, K. Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation. FEMS Microbiol. Lett. 2012, 330, 140-147.

2011

47. Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjho, A.; , Structure-Based Design, Synthesis, and Evaluation of Peptide-mimetics SARS 3CL Protease Inhibitors. J. Med. Chem. 2011, 54, 7962-7973.
46. Konno, H.; Nosaka, K.; Akaji, K. Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella mirabilis. Tetrahedron 2011, 67, 9067-9071.
45. Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H. Synthesis and cytotoxicity of callipeltin B analogues. Bioorg. Med. Chem. Lett. 2011, 21, 4865-4868.
44. Kikuchi, M.; Nosaka, K.; Akaji, K.; Konno, H. Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp. Tetrahedron Lett. 2011, 52(30), 3872-3875.
43. Toho, K.; Abe, N.; Yamada, T.; the late Ito, Y.; Konno, H.; Kuwahara, S.; Kiyota. H. Synthesis of N1- and N8(g-L-Glutamyl)spermidines and (g-L-glutamiyl)putrescine. Lett. in Org. Chem. 8, 1-5.

2010

42. Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K. Synthesis of solamin type mono-THF acetogenins using cross-metathesis, Tetrahedron, 2010, 66, 7946-7953.
41. Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K. Evaluation of Retro-Inverso Modifications of HTLV-1 Protease Inhibitors containing a Hydroxyethylamine Isoster. Bioorg. Med. Chem. 2010, 18, 2720-2727.
40. Oasa, M.; Hattori, Y.; Konno, H.; Makabe, H. Synthesis of Annonacin isolated from Annona densicoma, Biosci. Biochem. Biotechnol. 2010, 74 (6), 1274-1275.
39. Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K. Synthetic Studies on Callipeltins: stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine. Heterocycles 2010, 81(1), 79-89.

2009

38. Tanaka, M.; Tanaka, T.; Ohta, S.; Kawakami, T.; Konno, H.; Akaji, K.; Aimoto, S.; Saito, H. Evaluation of Lipid-Binding Propaties of the N-Terminal Helical Segments in Human Apolipoprotein A-I Using Fragment Peptides. J. Peptide Sci. 2009, 15 (1), 36-42.
37. Makabe, H.; Kuwabara, A.; Hattori, Y.; Konno, H. A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata. Heterocycles 2009, 78 (9), 2369-2376.
36. Konno, H.; Aimoto, S.; Smith, S. O.; Nosaka, K.; Akaji, K. Synthesis of [19.35.36-13C3]-Labeled TAK779 as a moleculer probe. Bioorg. Med. Chem. 2009, 17, 5769-5774.

2008

35. Konno, H.; Okuno, Y.; Makabe, H.; Nosaka, K.; Onishi, A.; Abe, N.; Sugimoto, A.; Akaji, K. Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata. Tetrahedron Lett. 2008, 49 (5), 782-785.
34. Onozuka, M.; Konno, H.; Kawasaki, Y.; Akaji, K.; Nosaka, K. Possible involvement of thiaminase II encoded by the THI20 gene in thiamine salvage of Saccharomyces cerevisiae, J. FEMS Yeast Research, 2008, 8 (2), 266-275.
33. Hattori, N.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H. Synthesis of Pyranicin and its Inhibitory Action with Bovine Heart Mitochondrial Complex I. Org. Lett. 2008, 10 (5), 717-720. (SYNFACTS, 2008, 8, 787.)
32. Furuhata, S.; Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H. Total synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex I. Tetrahedron, 2008, 64, 7695-7703.
31. Nosaka, K.; Onozuka, M.; Konno, H.; Akaji, K. Thiamin-dependent transactivation activity of PDC2 in Saccharomyces, FEBS Lett. 2008, 582 (29), 3991-3996.
30. Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Nosaka, K. Evaluation of Peptide Aldehyde Inhibitors using R188I Mutant of SARS 3CL Protease as a proteolysis-resistant mutant, Bioorg. Med. Chem. 2008, 16, 9400-9408.

2007

29. Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.; Synthesis of (17S, 18S)- and (17R, 18R)-tonkinelin and their inhibitory action with bovine heart mitochondorial complex I. Bioorg. Med. Chem. 2007, 15, 3026-3031.
28. Bang, J. K.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Tatsumi, T.; Akaji, K.; Studies on Substrate Specificity at PR/p3 Cleavage Site of HTVL-1 Protease. Int. J. Peptide Res., 2007, 13, 173-179.
27. Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Nosaka, K.; Akaji, K. Total Synthesis of Miraziridine A and Identification of Its Major Reactive Site for Cathepsin B. Tetrahedron, 2007, 63 (38), 9502-9513.
26. Konno, H.; Aoyama, S.; Nosaka, K.; Akaji, K. Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives and Identification of the Absolute Configration in Callipeltin E, Synthesis, 2007, (23), 3666-3672.

2006

25. Makabe, H.; Kimura, Y.; Higuchi, M.; Konno, H.; Murai, M.; Miyoshi, H.; Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15S, 16S, 21S)-rollicosin and squamostolide, and their inhibitory action with bovine heart mitochondeial complex I. Bioorg. Med. Chem. 2006, 14, 3119-3130.
24. Naka, H.; Teruya, K.; Bang, J. K.; Aimoto, S.; Tatsumi, T.; Konno, H.; Nosaka, K.; Akaji, K.; Evaluations of Substrate Specificity and Inhibition at PR/p3 Cleavage Site of HTLV-1 Protease. Bioorg. Med. Chem. Lett. 2006, 16, 3761-3764.
23. Hattori, Y.; Kimura, Y.; Moroda, A.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H. Synthesis of Murisolin, (15R, 16R, 19R, 20S)-Murisolin-A, (15R, 16R, 19R, 20S)-16,19-cis-Murisolin-A, and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I. Chemistry-Asian Journal 2006, 1, 894-904.
22. Konno, H.; Kusumoto, S.; Kanai, S.; Yamahana, Y.; Nosaka, K.; Akaji, K.; First syntheses of Trans- and Cis-dendrochrysanines. Heterocycles, 2006, 68 (12), 2579-2585.

2005

21. Makabe, H.; Higuchi, M.; Konno, H.; Murai, M.; Miyoshi, H.; Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15S, 16S, 21S)-rollicosin. Tetrahedron Lett. 2005, 46, 4671-4675.
20. Onozuka, M.; Konno, H.; Akaji, K.; Nishino, H.; Nosaka, K.; Molecular Cloning and Analysis of the 5’-Flanking Region of the Human Thiamin Pyrophosphokinase gene. J. Nutr. Sci. Vitaminol. 2005, 51(4), 274-277.1
19. Nosaka, K.; Onozuka, M.; Konno, H.; Kawasaki, Y.; Nishino, H.; Sano, M.; Akaji, K.; Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae, Mol. Microbiol. 2005 58(2), 467-479.
18. Bang, J. K.; Naka, H.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.; Solid-Phase Synthesis of Olefin-containing Inhibitors for HTLV-1 Protease using the Horner-Emmons Reaction. J. Org. Chem. 2005, 70 (25), 10596-10599.

2004

17. Konno, H.; Hiura, N.; Makabe, H.; Abe, M.; Miyoshi, H.; Synthesis and Mitochondrial Inhibition of Dihydroxy-Cohibin A, Non-THF Annonaceous Acetogenin Analogue. Bioorg. Med. Chem. Lett. 2004, 13, 629-632.
16. Makabe, H.; Miyawaki, A.; Takahashi, R.; Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Synthesis of Two Possible Diastereoisomers of Reticulatain-1. Tetrahedron Lett., 2004, 45, 973-977.
15. Makabe, H.; Hattori, Y.; Kimura, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Tanaka, A.; Oritani, T. Total Synthesis of cis-Solamin and Its Inhibitory Action with Mitochondrial Complex I. Tetrahedron 2004, 60, 10651-10657.

2003

14. Konno, H.; Makabe, H.; Structural Revision of Epoxyrollins A and B, Biosynthetic Precursor of Annnonaceous Acetogenins. Biosci. Biotechnol. Biochem., 2003, 67, 6, 1438-1441.
13. Konno, H.; Toshiro, E.; Hinoda, N.; An Epoxide Ring-Opening Reaction via Hypervalent Silicates Intermediate: Synthesis of Statine. Synthesis, 2003, 2161-2164. (有機合成化学協会誌、2003年6月号)
12. Makabe, H.; Okajima, M.; Konno, H.; Kamo, T.; Hirota, M.; Efficient Synthesis of Akolactone via Pd-Catalyzed Carbonylation. Biosci. Biotechnol. Biochem., 2003, 67, 12, 2658-2660.

2002

11. Koide, T.; Yuguchi, M.; Kawakita, M.; Konno, H.; Metal Assisted Stabilization and Probing of Collagenous Triple Helices. J. Am. Chem. Soc. 2002, 124, 9388-9289.
10. Konno, H.; Hiura, N.; Yanaru, M.; Syntheses of (4S, 5R)- and (4R, 5S)-Muricatacins and (4R, 5S)-aza-muricatacin, Unnatural Analogues of The Annonaceous Acetogenin. Heterocycles, 2002, 57, 10, 1793-1797.

1999

9. Konno, H.; Ogasawara, K.; A Practical Preparation of Versatile Cyclohexenoid Chiral Building Blocks. Synthesis, 1999, 1135-1140.
8. Yoshida, N.; Konno, H.; Kamikubo, T.; Takahashi, M.; Ogasawara, K.; Preparation of a Synthetic Equivalent of Chiral Methyl 2,5-Dihydroxycyclohexane 1,4-dienecarboxylate. Tetrahedron: Asymmetry, 1999, 10, 3849-3857.

1998

7. Konno, H.; Kishi, M.; Hiroya, K.; Ogasawara, K.; An Enantio- and Diastereoselective Synthesis of (-)-Isoretronecanol and (+)-Trachelanthamidine from A Meso Precursor. Heterocycles, 1998, 49, 22-26.
6. Konno, H.; Ogasawara, K.; Enantioselective Construction and Utilization of 2-(cyclohex-2-enyl)phenols. Synlett, 1998, 1004-1008.

1997

5. Konno, H.; Hiroya, K.; Ogasawara, K.; A New Tactic for Diastereo- and Enantilcontrolled synthesis of (-)-Malyngolide via Catalytic Meso-Asymmetrization. Tetrahedron Lett., 1997, 38, 6023-6026.

1996

4. Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.; Synthesis of Squamostanal-A. Biosci. Biotechnol. Biochem., 1996, 60, 526-527.
3. Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.; Synthesis of Two Possible Diastereoisomers of the Epoxy Lactone Proposed for an Annonaceous Acetogenins, Epoxyrollin A. Tetrahedron, 1996, 52, 9399-9408.
2. Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.; Total Synthesis of (15S, 16R, 19S, 20R, 34S)-Diepomuricanin. Tetrahedron Lett., 1996, 37, 5393-5396.

1995

1. Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.; Synthesis of Two Possible Diastereoisomers of the Lactone Proposed for Epoxyrollin A. Biosci. Biotechnol. Biochem., 1995, 59, 2355-2357.