ORIGINAL PAPERS (2019-2024)

ORIGINAL PAPERS (2024)
 
Che, S.; Konno, H.; Makabe, K. SpyTag peptide with alkoxyl aspartic acids for pH-dependent activation of the SpyCatcher/Tag system. Bioconjugate Chem. 2024, in press.
 
Li, Y.;　Takamatsu, K.; Aota, T.; Konno, H. Synthesis and structural revision of antatollamides A and B, cyclic hexapeptide dimers. Org. Lett. 2024, in press.
 
Soltan, O. M.; Abdel-Aziz, S.; Shaykoon, M.; Osawa, K.; Narumi, A.; Abdel-Aziz, M.; Konno, H. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, molecular docking, and Bioactivity Evaluation. Bioorg. Med. Chem. Lett. 2024, 102, 129673. DOI10.1016/j.bmcl.2024.129673.
 
Horaguchi, Y.; Yokomichi, M.; Takahashi, M.; Xu, F.; Konno, H.; Makabe, K.; Yano, S. Addition of α-1,3-glucan-binding domains to α-1,3-glucanase Agn1p from Schizosaccharomyces pombe enhances hydrolytic activity of insoluble α-1,3-glucan. J. Gen. Appl. Microbiol. 2024, in press.
 
ORIGINAL PAPERS (2023)
 
Takahashi, M.; Yano, S. Horaguchi, Y.; Otsuka, Y.; Suyotha, W.; Makabe, K.; Konno, H.; Kokeguchi, S. α-1,3-Glucanase from Gram-negative bacteria Flavobacterium sp. EK-14 hydrolyzes fungal cell wall a-1,3-glucan. Sci. Rep. 2023, 13, 21420. DOI10.1038/s41598-023-48627-y.
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Osawa, K.; Abdel-Aziz, M.; Konno, H. Development and assessment of 1,5-diarylpyrazole/oxime hybrids targeting EDFR and JNK-2 as antiproliferative agents: A comprehensive study through synthesis, molecular docking and evaluation. Molecules 2023, 28, 6521. DOI10.3390/molecules28186521.
 
Xu, F.; Okada, M.; Makabe, K.; Konno, H. Synthesis and evaluation of L-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors. Phytochem. Lett. 2023, 57, 239-247. DOI10.1016/j.phytol.2023.08.014
 
Okawara, A.; Hada, K.; Kurotani, R.; Teruya, K.; Konno, H. Design of the peptide C-terminus protecting group and application for the peptide fragment coupling reaction. Tetrahedron Lett. 2023, 127, 154665. DOI10.1016/j.tetlet.2023.154665.
 
Horaguchi, Y.; Takahashi, M.; Takamatsu, K.; Konno, H.; Makabe, K.; Yano, S. Heterologous expression of α-1,3-glucanase Agn1p from Schizosaccharomyces pombe, and efficient production of nigero-oligosaccharides by enzymatic hydrolysis from solubilized α-1,3;1,6-glucan. Biosci. Biotechnol. Biochem. 2023, 87, 1219-1228. DOI10.1093/bbb/zbad094.
 
Takamatsu, K.; Suzuki, R.; Matsunaga, A.; Katagiri, H.; Konno, H. Structure activity relationship study of NHPI derivatives for ReD-A method and the application for the Fmoc-SPPS. J. Org. Chem. 2023, 88, 1319-1326. DOI10.1021/acs.joc.2cc01342
 
Horaguchi, Y.; Yano, S.; Takamatsu, K.; Otsuka, Y.; Suyotha, W.; Wakayaama, M.; Konno, H. Nigero-oligosaccharide production by enzymatic hydrolysis from alkaline pretreated a-1,3-glucan. J. Biosci. Bioeng. 2023, 135, 182-189. DOI10.1016/j.biosc.2023.01.003
 
 
ORIGINAL PAPERS (2022)
 
Yano, S.; Terada, S.; Fukushi, M.; Otsuka, Y.; Mizunuma, S.; Asakura, S.; Kawai, T.; Konno, H.; Endo, M.; Nonomura, Y. Antimicrobial activity of polysorbate 80–iodine complex: Polysorbate 80 firmly retains iodine. J. Oleo. Sci. 2022, 71, 1639-1645. DOI10.5650/jos.ess22115
 
Kadowaki, T.; Kainuma, R.; Kato, S.; Konno, H. Synthesis and configuration confirmation of ATHOD fatty amino acid residue in burkholdines. J. Nat. Prod. 2022, 85, 2052-2061. DOI10.1021/acs.jnatprod.2c00469 = Selected cover picture
 
Otsuka, Y.; Sato, K.; Yano, S.; Kanno, H.; Tsuhako, H.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. GH16 type β-1,3-glucanase from Lysobacter sp. MK9-1 enhances antifungal activity of GH 19 type chitinase, and its glucan-biding domain binds to fungal cell-wall. J. Appl. Glycosci. 2022, 69, 49-56. DOI10.5458/jag/jag.JAG-2022_0002
 
Konno, H.; Sasaki, M; Sano, H.; Osawa, K.; Nosaka, K.; Yano, S. Hydrophobicity and antifungal potentiation efficiency of cyclic peptide burkholdine analogues. Molecules 2022, 27, 1191. DOI10.3390/molecules27041191
 
Otsuka, Y.; Sasaki, K.; Suyotha, W.; Hurusawa, H.; Miyazawa, K.; Konno, H.; Yano, S. Construction of fusion protein consisting of α-1,3-glucan binding domains and tetrameric red fluorescent protein, which is involved in aggregation of α-1,3-glucan and inhibition of fungal biofilm formation. J. Biosci. Bioeng. 2022,133, 524-532. DOI10.1016/j.biosc.2022.02.008
 
Tan, A.; Takamatsu, K.; Xu, F.; Osanai, S.; Konno, H. Application of reversible detection method for N-terminus amino groups: solid phase synthesis of stylissatin B. Heterocycles 2022, 105, 397-405. DOI10.3987/COM-21-S(R)6
 
Ito, Y.; Araki, T.; Shiga, S.; Konno, H.; Makabe, K. Surface engineering of TOP7 to facilitate structure determination. Int. J. Mol. Sci. 2022 23, 701. DOI10.3390/ijms23020701
 
Teruya, K.; Iwabuchi, S.; Watanabe, Y.; Tsuchida, R.; Watanabe-Matsui, M.; Konno, H.; Doh-ura, K. Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains. BBA General Subjects 2022, 1866, 130094. DOI10.1016/j.bbagen.22022.130094
 
 
ORIGINAL PAPERS (2021)
 
 
Sasaki, M.; Kadowaki, T.; Kato, S.; Chida, S.; Yano, S.; Nosaka, K.; Konno, H. Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues. Tetrahedron Lett. 2021, 87, 153542. DOI10.1016/j.tetlet.2021.153542
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shams, R.; Tajiri, M.; Abdel-Aziz, M.; Konno, H. Design, synthesis, molecular docking and biological evaluation of novel 1,5-diarylpyrazole-N,O-dimethyl hydroxamate derivatives as antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 214-225.
 
Tan, A.; Xu, F.; Yokoyama, C.; Yano S.; Konno, H. Design, synthesis, and evaluation of the self-assembled antimicrobial peptides derived from the ovalbumin-derived peptide TK913 J. Pept. Sci. 2021, e3375. DOI10.1002/psc.3375
 
Takamatsu, K.; Kasai, M.; Nishizawa, H.; Suzuki, R.; Konno, H. Aerobic oxidation of aldehydes with N-hydroxyphthalimide derivatives. Tetrahedron Lett. 2021, 81, 153320. DOI10.1016/j.tetlet.2021.153320
 
Homma, T.; Kobayashi, S.; Marcus, C.; Konno, H.; Yokoyama, C.; Fujii, J. Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide 2021, 115, 34-43.  DOI10.1016/j.niox.2021.07.003.
 
Nagaoka, K.; Nakano, A.; Han, J.; Sakamoto, T.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Comparative study of different chiral ligands for dynamic kinetic resolution of amino acid. Chirality 2021, 33, 685-702. DOI10.1002/chir.23350
 
Kobayashi, S.; Homma, T.; Okumura, N.; Han, J.; Nagaoka, K.; Sato, H.; Konno, H.; Yamada, S.; Takao, T.; Fujii, J. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Free Radical Bio. Med. 2021, 174, 12-27. 
DOI10.1016/j.freeradbiomed.2021.07.036
 
Zou, Y.; Yin, Z.; Mei, H.; Konno, H.; Moriwaki, H.; Soloshonok, V. A.; Han, J. Aldol addition-cyclization reaction cascade on platform of chiral Ni(II) complex of glycine Schiff base. Urk. Bioorg. Acta 2021, 16, N1, 3-9. DOI10.15407/bioorganica2021.01.003.
 
Solman, O. M.; Shoman, M. E.; Abdel-Aziz, S. A.; Nagaoka, K.; Narumi, A.; Konno, H.; Abdel-Aziz M. Design, synthesis, molecular modeling and biological evaluation of novel 1,5-diarylpyrazole carboxamide derivatives s antiproliferative agents. J. Adv. Biomed. Pharm. Sci. 2021, 4, 152-159.
 
Li, Z.; Wang, N.; Mei, H.; Konno, H.; Soloshonok, V. A.; Han, J. Asymmetric Synthesis of a-difluorinated b-amino sulfones via detrifluoroacetylative Mannich reactions. Eur. J. Org. Chem. 2021, 3035-3038. DOI10.1002/ejoc.202100350
 
Zou, Y.; Takeda, R.; Han, J.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. Asymmetric synthesis of N-Fmoc-(S)-7-aza-triptophane via alkylation of chiral nucleophilic glycine equivalent. Eur. J. Org. Chem. 2021, 2962-2965.  DOI10.1002/ejoc.202100485
 
Mihara, H.; Watanabe, Y.; Konno, H. Preparation of pyridine derivatives from the corresponding 5-acetal-1-carbonyl compounds by acid promoted cyclization. Heterocycles 2021, 102, 1314-1329. DOI10.3987/COM-21-14457
 
Narumi, A.; Rachi, R.; Yamazaki, H.; Kawaguchi, S.; Kikuchi, M.; Konno, H.; Osaki, T.; Okamoto, Y.; Shen, X.; Kakuchi, T.; Kataoka, H.; Nomoto, A.; Yano, S. Maltotriose-chlorin e6 conjugate linked via tetraethyleneglycol as advanced photosensitizer for photodynamic therapy. Synthesis and antitumor tests against canine and mouse mammary carcinoma cells. ACS Omega 2021, 6, 7023-7033. DOI10.1021.qcsomega.0c06316
 
Tokairin, Y.; Konno, H.; Noireau, A.; Wast, C.; Lesellier, E.; Moriwaki, H.; Soloshonok, V. A.; Nicolas, C.; Gillaizeau, I. Synthesis of the two enantiomers of b-phosphorus-containing amino acids via hydrophosphinylation and hydrophosphonylation of chiral Ni(II)-complexs. Org. Chem. Front. 2021, 8, 2190. DOI10.1039/d1qo00159k
 
Tajiri, M.; Yamada, R.; Hotsumi, M.; Makabe, K.; Konno, H. The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. Eur. J Med. Chem. 2021, 215, 113289. DOI10.1016/j.ejmch.2021.113289
 
Alfayomy, A. M.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shaykoon, M. Sh. A.; Narumi, A. Konno, H.; Abou-Seri, S. M.; Ragab, F. A. F. Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies. Bioorg. Chem. 2021, 108, 104555. DOI:10.1016/j.bioorg.2020.104555
 
Shigeno, Y.; Han, J.; Soloshonok, V. A.; Moriwaki, H.; Fujiwara, W.; Konno, H. Asymmetric synthesis of (S)-3-methyleneglutamic acid and its N-Fmoc derivative via Michael addition of chiral glycine Schiff base Ni(II) complex with enol tosylates. Chirality 2021, 33, 115-123. DOI10.10072/chir.23291
 
Yano, S.; Kanno, H.; Tsunako, H.; Ogasawara, S.; Suyotha, W.; Konno, H.; Makabe, K.; Uechi, K.; Taira, T. Cloning, expression, and characterization of a GH 19 type chitonase with antifungal activity from Lysobacter sp. MK9-1. J. Biosci. Bioeng. 2021, 131, 348-355.
 
Suyotha, W.; Cheirslip, B.; Matsuba, S.; Konno, H.; Yano, S. Production of chitosanase by Lentzea sp. OUR-I1 using acid-pretreated shrimp shell in an air-lift bioreactor and the feasibility of utilizing the residual biomass. Waste and Biomass Valorization 2021, 12, 2445-2458. DOI10.1071/s12649-020-01191-2
 
ORIGINAL PAPERS (2020)
 
Han, J.; Li, Z.; Wang, L.; Huang, Y.; Mei, H.; Konno, H.; Moriwaki, H.; Soloshonok, V. A. Asymmetric Mannich Reactions of (S)-N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldiminess with yne-nucleophiles. Beilstein J. Org. Chem. 2020, 16, 2671-2678. DOI10.3762/bjoc.16.217
 
Fu, B.; Takeda, R.; Zou, Y.; Konno, H.; Moriwaki, H.; Ave H.; Han, J.; Izawa, K.; Soloshonok, V. A. Asymmetric synthesis of (S)-a-(octyl)glycine via alkylation of Ni(II)-complex of chiral glycine Schiff base. Chirality 2020, 32, 1354-1360. DOI10.1002/chir.23281
 
Konno, H.; Yasumiishi, H.; Aoki, R.; Nitanai, I.; Yano, S. Detection of thiol functionality and disulfide bond formation by polyoxometalate. ACS Comb. Sci. 2020, 22, 745-749. DOI10.1021/acscombsci.0c00176
 
Hotsumi, M.; Tajiri, M.; Makabe, K.; Konno, H. Design, synthesis and evaluation of diaryl g-dihydropyrone derivatives as cyclocurcumin mimetics and inhibitors of the aggregation amyloid b. Bioorg. Chem. 2020,104, 104302. DOI:10.1016/j.bioorg.2020.104302
 
Sugawara, K.; Konno, H.; Ito, T.; Sato, S. Synthesis and evaluation of b-galactosidase-targeting spin-label probe: 5-O-b-D-galactosyl-5-hydroxy-1,1,3,3- tetramethylisoindoline-2-oxyl. Heterocycles 2020, 100, 1799-1815. DOI:10.3987/COM-20-14317
 
Namioka, S.; Yoshida, N.; Konno, H.; Makabe, K. Residue-specific binding mechanisms of Thioflavin T to a surface of flat b-sheets within a peptide self-assembly mimic. Biochemistry 2020, 59, 2782-2787. DOI10.1021/acsbiochem.0c00280 = Selected Cover Picture
 
Tan, A.; Suzuki, R.; Yokoyama, C.; Yano, S.; Konno, H. Antimicrobial activity and secondary structure of a novel peptide derived from ovalbumin. J. Pep. Sci. 2020, 26, e3276. DOI10.1002/psc.3276
 
Oyama, K.; Han, J.; Moriwaki, H.; Soloshonok, V. A.; Konno, H. Synthesis of Ahod moiety of ralstonin A using amino acid Schiff base Ni(II)-complex chemistry. Helv. Chimica Acta. 2020, 103, e2000077. DOI10.1002/hlca.20200077
  
Suzuki, R.; Konno, H. Stain protocol for the detection of N-terminal amino groups during solid phase peptide synthesis. Org. Lett. 2020, 22, 3309-3312. DOI10.1021/acs.orglett.0c00445 = Selected Cover Picture
 
Abouelela, M. E.; Orabi, M. A. A.; Abdelhamid, R. A.; Abdelkader, S. A.; Darwish, F. M. M.; Hotsumi, M.; Konno, H. Anti-Alzheimer’s flavanolignans from Ceiba pentandra Aerial Parts. Fitoterapia 2020, 143, 104541. DOI10.1016/fitote.2020.104541
 
Kobayashi, S.; Ukeda, Y.; Shigeno, Y.; Konno, H.; Fujii, J. g-Glutamylcysteine synthetase and g-glutamyl transferase as differential enzymatic sources for g-glutamylpeptides in mice. Amino Acids 2020, 52, 555-566. DOI10.1007/s00726-020-02835-2
 
Nagaoka, K.; Mei, H.; Guo, Y.; Han, J.; Konno, H.; Moriwaki, H.; Soloshonok, V. A. Michael addition reactions of chiral glycine Schiff base Ni(II)-complex with 1-(1-phenylsulfonyl)benzene. Chirality 2020, 32, 885-893. DOI10.1002/chir.23203
 
Abdelhamid, R. A.; Nafady, A. M.; Abouelela, M. E.; Konno, H.; El-Khayat, E. S. Molecular simulation of polyketides isolated from the endophyte Phiilaphora Verrucosa. Trends Phytochem. Res. 2020, 4, 9-16.
 
Romoff, T. T.; Ignacio, B. G.; Mansour, N.; Palmer, A. B.; Creighton, C. J.; Abe, H.; Mirowaki, H.; Han, J; Konno, H.; Soloshonok, V. A. Large-scale synthesis of the glycine Schiff base Ni(II) complex derived from (S)- and (R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide. Org. Process Res & Devlop. 2020, 24, 294-300. DOI10.1021/acs.oprd.9b00399
 
Tokairin, Y.; Shigeno, Y.; Han, J.; Röschenthaler, G.-V.; Konno, H.; Moriwaki, H.; Soloshonok, V. A. Asmmetric synthesis of 4,4-(Difluoro)glutanic acid via chiral Ni(II)-complexes of dehydroalanine Schiff bases. Effect of the chiral ligands structure on the stereochemical outcome. Chemistry Open 2020, 9, 93-96. DOI10.1002/open.201900343
 
ORIGINAL PAPERS (2019)
 
Han, J.; Takeda, R.; Liu X.; Konno, H.; Abe, H.; Hiramatsu, T.; Moriwaki, H.; Soloshonok, V. A. Preparative method for asymmetric synthesis of (S)-2-amino-4,4,4-trifluorobutanoic acid derivatives. Molecules 2019, 24, 4521. DOI10.3390/molecules24244521
 
Huynh, N. T.; Suyotha, W.; Yano, S.; Konno, H.; Cheisilp, B.; Wakayama, M. Low-cost production of chitosanolytic enzymes from Lentzea sp. strain OUR-I1 for the production of antimicrobial substances against food-borne pathogens. Int. Food Res. J. 2019, 26, 1293-1304.
 
Uenoyama, R.; Miyazaki, M.; Miyazaki, T.; Shigeno, Y.; Tokairin, Y.; Konno, H.; Yamashita, T. LC-ESI-MS/MS quantification of carnosine, anserine, and balenine in meat sample. J. Chromatogr. B 2019, 1132, 121826. DOI10.1016/j.chromb.2019.121826
 
Mihara, H.; Miyakoshi, T.; Kikuchi, Y.; Konno, H. The one-pot synthesis of pyridine derivatives from the corresponding 1,5-dicarbonyl compounds. Heterocycles 2019, 90, 1375-1383. DOI10.3987/COM-10-14151
 
Yu, Z.; Xu, F.; Li, Y.; Konno, H.; Hu, L.; Yang, S. Tetraethylammonium fluoride-mediated a green hydrogen transfer process for selective reduction of biomass-derived aldehydes. Curr. Green Chem. 2019, 6, 127-134. DOI10.2174/2213346106666190830115519
 
Tokairin, Y.; Soloshonok, V. A.; Konno, H.; Moriwaki, H.; Röschenthaler, G.-V. Convenient synthesis of racemic 4,4-difluoro glutamic acid derivative via Michael-type additions of Ni (II)-complex of dehydroalanine Schiff base. J. Fluorine Chem. 2019, 227, 109376. DOI10.1016/j.jfluchem.2019.109376
 
Hotsumi, M.; Tajiri, M.; Nikaido, Y.; Sato, T.; Makabe, K.; Konno, H. Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid b aggregation inhibitor. Bioorg. Med. Chem. Lett. 2019, 29, 2157-2161. DOI10.1016/j.bmcl.2019.06.052
 
Okukawa, M.; Watanabe, T.; Miura, M.; Konno, H.; Yano, S.; Nonomura, Y. Antibacterial activity of 1,2-alkanediol against Staphylococcus aureus and Staphylococus epidermidis. J. Oleo Sci. 2019, 68, 759-763. DOI10.5650/jos.ess19074
 
Kato, S.; Sasaki, M.; Yano, S.; Konno, H. Synthesis of burkholdine analogue containing the b-hydroxytyrosine. Biosci. Biotechnol. Biochem. 2019, 83, 1216-1219. DOI10.1080/09168451.2019.1594678
 
Kobayashi, S.; Tokairin, Y.; Miyakoshi, T.; Saito, T.; Nagaoka, K.; Ikeda, Y.; Fujii, J.; Konno, H. Quantitative analysis of g-glutamylpeptides by liquid chromatography-mass spectrometry and application for studying liver injury and g-glutamyltransferase assay. Anal. Biochem. 2019, 578, 13-22. DOI10.1016/j.ab.2019.04.023
 
Yano, S.; Hori, Y.; Kijima, T.; Konno, H.; Suyotha, W.; Takagi, K.; Wakayama, M. Construction of cellulose binding domain fusion FMN-dependent NADH-azoreductase and glucose 1-dehydrogenase for development of flow injection analysis with fusion enzymes immobilized on cellulose. J Appl. Glycosci. 2019, 66, 65-72. DOI10.5458/jag.jag.JAG-2018_0011
 
Watanabe, T.; Yamamoto, Y.; Miura, M.; Konno, H.; Yano, S.; Nonomura, Y. Systematic analysis of selective bacterial activity of fatty acids against Staphylococcus aureus with minimal inhibitory concentration and minimal bactericidal concentration. J. Oleo Sci. 2019, 68, 291-296. DOI10.5650/jos.ess18220
 
Nosaka, K.; Uchiyama, R.; Tadano, K.; Endo, Y.; Hayashi, M.; Konno, H.; Mimuro, H. Thiamin transport in Helicobacter pylori lacking the de novo synthesis of thiamin. Microbiology 2019, 165, 224-232. DOI10.1099/mic.0.000765
 
Kameda, R.; Soma, T.; Kobayashi, K.; Uchiyama, R.; Nosaka, K.; Konno, H.; Akaji, K.; Hattori, Y. Convergent synthesis of trans-2,6-disubstituted piperidine alkaloid, (-)-iso-6-spectaline by palladium-catalyzed cyclization. Chem. Pharm. Bull. 2019, 67, 253-257.
 
Miyakoshi, T.; Konno, H. Improved synthesis of 2,4,6-trialkylpyridines from 1,5-diketoalkanes: total synthesis of anibamine. Org. Biomol. Chem. 2019, 17, 2896-2905. DOI10.1039/C8OB02723D
 
Tokairin, Y.; Soloshonok, V. A.; Moriwaki, H.; Konno, H. Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid phase peptide coupling. Amino Acids 2019, 51, 419-432. DOI10.1007/s00726-018-2677-5
 
 

REVIEW ARTICLES

Konno, H.; Teruya, K. Design, synthesis and evaluation of catechol-based amyloid beta aggregation inhibitors. Heterocycles 2023, 106, 797-818. DOI: 10.3987/REV-22-999
 
今野博行, N-ヒドロキシフタルイミドの特性を活かした新しい活用法. Peptide Newsletter Japan, 2021年10月, No. 122, pp2-5.
 
Liu, A.; Han, J.; Nakano, A.; Konno, H.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V. A. New pharmaceuticals approved by FDA in 2020: small-molecule drugs derived from amino acids and related compounds. Chirality 2021, 34, 86-103. DOI10.1002/chir.23376
 
Han, J.; Lyutenko, N. V.; Sorochinsky, A. E.; Okawara, A.; Konno, H.; White, S.; Soloshonok, V. A. Tailar-made amino acids in pharmaceutical industry: synthetic approaches to aza-tryptophan detivatives.  Chem. Eur. J. 2021, 27, 17510-17528. DOI10.1002/chem.202102485 = Selected Frontispiece Picture
 
Soltan, O.; Shoman, M.; Abdel-Aziz, S.; Narumi, A.; Konno, H.; Abdel-Aziz, M. Molecular hybrids: A five years survey on structure of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. Eur. J. Med. Chem. 2021, 225, 113768. DOI10.1016/j.ejmech.2021.113768
 
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Peptidemimetics and peptide-based blockbuster drugs. Curr. Org. Chem. 2021, 25, 1627-1658. DOI10.2174/1385272825666210610155047
 
Han, J.; Konno, H.; Sato, T.; Izawa, K.; Soloshonok, V. A. Tailor-made amino acids in the design of small-molecule blockbuster drugs. Eur. J. Med. Chem. 2021, 220, 113448. DOI10.1016/j.ejmech.2021.113448
 
Abdelrahman, K. S.; Hassan, H. A.; Abdel-Aziz, S.; Marzouk, A.; Narumi, A.; Konno, H.; Abdel-Aziz, M. JNK signaling as target for anticancer therapy. Pharmacological Reports 2021,73, 405-434. DOI10.1007/s43440-021-00238-y
 
今野博行、赤路健一、コロナウイルスSARS 3CL プロテアーゼの作製とその阻害剤創製. 有機合成化学協会誌, 2021,79, 2-10.
 
Reda A. Abdelhamid and Hiroyuki Konno, Cyclic depsipeptide, Callipeltins, Top Heterocyclic Chem (2021) 58, 297-316. Marine Natural Products, Ed. Hiromasa Kiyota. Springer. DOI10.1007//7078_2020_47
 
Soloshonok, V. A.; Yin, Z.; Hu, W.; Zhang, W.; Konno, H.; Moriwaki, H.; Izawa, K.; Han, J. Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019. Amino Acids 2020, 52, 1227-1261. DOI10.1007/s00726-020-02887-4
  
Akaji, K.; Konno, H. Design and evaluation of anti-coronavirus agents based on molecular interactions with the viral protease. Molecules 2020, 25, 3920. DOI10.3390/molecules25173920
 
Han, J.; Butler, G.; Moriwaki, H.; Konno, H.; Soloshonok, V. A.; Kitamura, T. Kitamura electrophilic fluorination using HF as a source of fluorine. Molecules 2020, 25, 2116. DOI10.3390/molecules25092116
 
Han, J.; Romoff, T. T.; Moriwaki, H.; Mkrtchyan, A. F.; Saghyan, A. S.; Konno, H.; Soloshonok, V. A. Asymmetric synthesis of tailor-made amino acids using chiral Ni(II)-complexes of Schiff bases; An update of the recent literature. Molecules 2020, 25, 2739. DOI10.3390/molecules25122739